| 引用本文: | 王孝杰,李效东,刘东华,等.一种核—壳结构的枝化聚乙二醇大分子的合成.A Novel Method for Synthesis of Core-shell Type Branched PEG Macromolecule[J].国防科技大学学报,2006,28(3):37-39 ,70.[点击复制] |
| WANG Xiaojie,LI Xiaodong,LIU Donghua,et al.A Novel Method for Synthesis of Core-shell Type Branched PEG Macromolecule[J].Journal of National University of Defense Technology,2006,28(3):37-39 ,70[点击复制] |
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| 一种核—壳结构的枝化聚乙二醇大分子的合成 |
| 王孝杰1, 李效东1, 刘东华2, 刘克良3 |
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(1.国防科技大学 航天与材料工程学院，湖南 长沙 410073;2.湖南师范大学 化学化工学院，湖南 长沙 410081;3.军事医学科学院 毒物药物研究所，北京 100850)
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| 摘要: |
| 选择以三羟甲基氨基甲烷(Tris)为核，以单甲氧基聚乙二醇(mPEG)为外层分子，通过官能团反应，合成出一种核—壳型枝化PEG衍生物；利用叔丁氧羰基酸酐((Boc)2O)对Tris上的氨基进行保护，对mPEG端羟基依次进行羧基化、酰氯化等活化处理，通过酰氯与羟基的官能团反应合成出目标分子。产物分子保留了活性官能团氨基，为其进一步的修饰反应提供了保障。通过红外光谱分析、元素分析及分子量测定，证实了产物与目标分子的结构相吻合。 |
| 关键词: 氨基保护 枝化聚乙二醇 核—壳结构 合成 |
| DOI： |
| 投稿日期：2005-12-09 |
| 基金项目: |
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| A Novel Method for Synthesis of Core-shell Type Branched PEG Macromolecule |
| WANG Xiaojie1, LI Xiaodong1, LIU Donghua2, LIU Keliang3 |
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(1.College of Aerospace and Materials Engineering, National Univ. of Defense Technology, Changsha 410073, China;2.College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081，China;3.Institute of Pharmacology & Toxicology, Academy of Military Medical Science, Beijing 100850，China)
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| Abstract: |
| A novel core-shell type branched macromolecule was synthesized from the tris(hydroxymethyl) aminomethane(Tris) and the monomethoxypoly(ethylene glycol)(mPEG). The first step was to protect the amino group of Tris by using t-butyloxycarbonyl anhydride ((Boc)2O), then mPEG was activated by changing hydroxide terminal into acid chloride and carboxylation of mPEG was fulfilled before. The amino group was reserved so that it could be used as functional radical to modify the protein later. The product was confirmed to inosculate with FT-IR, EA and M.W. through infrared spectroscopic analysis, element analysis and mensuration of molecular weight. |
| Keywords: protection of amino group branched PEG core-shell synthesis |
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