| 引用本文: | 王正华,周婷婷.代谢网络结构特征的生物信息学研究.[J].国防科技大学学报,2010,32(1):107-111.[点击复制] |
| WANG Zhenghua,ZHOU Tingting.Bioinformatics for Macro-structural and Topological Properties of Metabolic Networks[J].Journal of National University of Defense Technology,2010,32(1):107-111[点击复制] |
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| 代谢网络结构特征的生物信息学研究 |
| 王正华, 周婷婷 |
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(国防科技大学 并行与分布处理国家重点实验室，湖南 长沙 410073)
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| 摘要: |
| 作为生物信息学的重要研究内容，近年来代谢网络结构特征方面的研究取得了许多成果。回顾了代谢网络的重构和表示方法，重点综述了代谢网络宏观结构特征所蕴含的生物学意义，以及拓扑特征所揭示的网络演化过程和网络稳健性信息，提出了目前研究中仍然存在的问题及可能的解决思路，并对将来的研究趋势进行了阐述。 |
| 关键词: 生物信息学 代谢网络 网络重构 宏观结构 拓扑特征 网络演化 网络稳健性 |
| DOI： |
| 投稿日期：2009-07-18 |
| 基金项目:国家自然科学基金资助项目(60603054，60773021) |
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| Bioinformatics for Macro-structural and Topological Properties of Metabolic Networks |
| WANG Zhenghua, ZHOU Tingting |
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(National Key Laboratory for Parallel and Distributed Processing, National Univ. of Defense Technology, Changsha 410073， China)
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| Abstract: |
| In the field of bioinformatics, recently more and more researches are launched on the studies of the structure and topology of metabolic networks. We first review the progress for metabolic network reconstruction and representation. Then we look into the macro-structural and topological properties of metabolic networks which are meaningful for uncovering how metabolic networks evolve and why they are robust. Finally we expound our viewpoints on the current issues and the prospective studies in this field. |
| Keywords: bioinformatics metabolic network network reconstruction macro-structure topology network evolution network robustness |
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