Osculating cone waverider configuration is an important design reference to the powered hypersonic vehicle. This paper parameterized the design process of OC waverider and engineering method was used to evaluate waverider's aerodynamic performances. Based on the orthogonal experiment, L/D ratio, volume and volume efficiency were chosen as optimized objective functions to optimize the configuration. CFD simulation shows that the optimized configuration has better L/D, volume, volume efficiency and uniform flow at the base, thus it is an important design reference in the hypersonic engine-airframe integration design.