This article researched the aerodynamic configuration design of the glide/skip trans-atmospheric vehicle(TAV) based on waverider with high lift-to-drag ratio. Firstly, design methods of waverider configuration were put forward, and the waverider shape changed from design parameters was fully investigated. Then, the performances of the optimized waveriders under the varieties of Mach number and differed optimization aims were compared and studied. Finally, a TAV configuration with high L-D ratio and high volumetric efficiency was obtained. The conclusion has important reference value to the research of TAV configuration and waverider.