In order to meet the requirements of multi-agents (MAS) emergency response simulation, the complexity of building a MAS emergency response simulation framework was firstly analyzed. Based on this, the Component Simulation Framework (CSF) was proposed and designed. Through using theories and methods of Ontology, Semantic Net and Production Rules Reasoning, the architecture of scene-modeling and evacuee agents-modeling which work as critical components of CSF were constructed. Finally, the test to the prototype system which is implemented as the framework was carried out, and the result shows that it can efficiently meet the requirements of multi-agents emergency simulation. 