Inspired by the circulatory secretion and paracrine of hormone, aimed at solving the problems such as low efficiency and complexity during the cellular communicating, a four-layer structural architecture for bioinspired self-healing hardware based on NoC (network on chip) and neighborhood connections was proposed. A self-healing hardware realizing an FIR (finite impulse response) filter based on the architecture was brought in to explain the architecture in detail. The hardware shows flexible routing ability and good fault-tolerant ability. It indicates that the structural architecture provides a new approach to design a self-healing hardware with high reliability. 