Based on the demand of the spacecraft protection against the orbital debris, numerical simulation of a new designed stuffed corrugation-cored sandwich under hypervelocity impact was carried out. The hypervelocity impact process was obtained, and thereby the perforation of the sandwich and the characteristics of the debris cloud were analyzed. It can be seen that the phenomenon of stuffed corrugation-cored sandwich under hypervelocity impact is similar to that of Whipple structure, but the head velocity of the debris cloud is lower and the expansion velocity and expansion angle is larger. With the impact velocity increasing from 3 km/s to 10 km/s, the size of the sandwich perforation increases accordingly and the shape of the perforation becomes more irregular. Furthermore, the epoxy stuffed in the sandwich absorbs most impact energy of the debris while the front plate and the corrugation core absorb less energy. The research can provide some references for the design of orbital debris shield.