In order to meet the RBDO (reliability-based design optimization) requirement for the life of turbine blade with film holes by automatic programmed control, the local parameterization method was proposed on the basis of the unstructured mesh, which significantly reduces the time costs of FEA (finite element analysis). The turbine blade was separated into two regions:the parameterized region and the non-parameterized region. After the meshes of the non-parameterized region and control points of the parameterized region were completed, only the meshes of parameterized region were required to be reconstructed when the geometry of film holes was updated. Compared with the global deformation method based on the structured mesh, the proposed method dramatically reduces the time costs of FEA while ensuring the accuracy of finite element calculation, which highly improves the efficiency of RBDO.