Unmanned swarm operation is becoming a new operation style that changes the shape of warfare. In response to the current problem that unmanned equipment experiments are relatively independent and lack of integrated closed-loop design and integrated verification means, a SoS(system-of-system) design, simulation and evaluation method was proposed. The method contains five stages:operational concept modeling and requirement analysis, SoS design concept and SoS design, infield simulation experiment and scheme exploration, SoS prototype development and evaluation optimization, and outfield integrated test and comprehensive decision. It innovates and develops theoretical methods, tool chains, and integrated environment for SoS design, simulation test, and evaluation optimization, which provides certain theoretical and technical support for the systematization intellectualization and actual combat of unmanned swarm.