In order to accurately and effectively determine the location selection of missile launch position, overcome the disadvantages of strong subjective factors and the difficulty to judge the pros and cons of the location selection scheme in the current position location process, a two-stage position location selection method based on GIS(geographic information system) and improved TOPSIS(technique for order preference by similarity to an ideal solution) was proposed. In the primary selection stage, the index system affecting the location selection of launch position was constructed, and the comprehensive weight of each index was obtained by using the improved analytic hierarchy process. Aiming at the quantitative index, the multi-loop buffer zone was established by GIS technology for spatial analysis, and the selection scheme of launch position location selection was obtained. In the precise selection stage, combined with the scores of each index of the alternative scheme, and aiming at the qualitative index, the grey correlation improved TOPSIS was used for comprehensive evaluation to obtain the optimal location scheme of missile launching position. Example verification shows that this method has good operability and applicability, and the influence of subjective factors is small, which can provide decision-making basis for the location selection of missile launching positions.