When a high-power pulsed Laser beam interacts with a target in the time of the order of microsecond，the experimental results show that the Laser-supported detonation wave yet occurs due to a sublimation of the target in a vacuum background. A compression wave generated by this Laser-supported detonation wave propagates into the target，this wave is a significant factor for damage of the target，but the recoil pressure of vaporization，the thermal stress and ablation damage of the target to irradiation by the high-power pulsed Laser are also factors that can not be neglected. Experiments also show that the follow-up Laser radiation can be shielded by the Laser-supported detonation wave when the Laser-supported detonation wave occurs in the vacuum background.