This paper applies Newton iterative method to computing basic firing data of ballistic missiles efficiently. In this paper, Newton iterative formula based on deviations of dropping point is deduced and the iterative program is designed, an example is given. Considering the relationship between the convergent speed of the iterative method and the initial value of parameters, the paper brings forward a method, which provides good initial values of parameters by using a reverse interpolation method based on prepared firing tables. The actual practice indicates that the method accelerates iteration rapidly. It is possible to design a standard trajectory of ballistic missiles quickly by using the method presented in this paper.