The dynamic scanning calorimetry (DSC) method was used to determine the reaction kinetic parameters of a hybrid resin of E-44/E-21(6∶4) with GA-327 as curing agent. Effects of rate of temperature increasing on the characteristics of DSC curves were investigated. Results suggest that the reaction of the hybrid epoxy resin with GA-327 can be described by the equation of dα/dt =2.27×10⁴exp(- 4764.65/T)(1-α)^0.861, and the curing procedure is then determined as 100℃ for 30min, and then 120℃ for 30min. The degree of curing reaction of the casting bodies of the hybrid epoxy resin reaches 95.7%, and tensile strength and flexure strength of the casting body are 62.71MPa and 97.92MPa, respectively.