Chemo-rheological of AFG-90 epoxy resin modified with new organic-inorganic hybrid nano-materials POSS was studied in this paper. A rheological model based on dual-Arrhenius equation was established and used to simulate chemo-rheological behavior of this resin system. The estimated viscosity of the model was in good agreement with that of the experiment in the initialization reaction stage. The processing window of the resin system can be well determined based on the rheological model.