The multidisciplinary system analysis models for tactical missile are derived, and the multidisciplinary design optimization (MDO) methods are established accordingly. MDO methods can gain the optimal design consistent with system design constraints and the solid rocket motor thrust time curve, which is a best match for exterior trajectory by looping execution between system design optimization and parallel subsystem solid rocket motor design optimization, thus the design cycle for tactical missile system and solid rocket motor can be greatly reduced. The tactic-technical specifications, including the motion state of 22 typical targets, are taken into account in the design optimization process of tactical missile.