Complexity of NAMD(Networked Air and Missile Defense) systems which is evolved in networked centric warfare makes researches on its modeling and simulation still stay in the initial exploring phase. Many novel characters of systems operation for this domain were introduced, and several models for it were developed from target，weapon and C2 (command and control) perspective respectively, eventually a typical simulation case of relay guidance was designed for models validation. Results analysis not only demonstrates the process of NAMD, but also push forward the effectiveness simulation of NAMD. 