The high-aspect-ratio low-speed near-space aircrafts may undergo very large deformation during flight, so a high demand of moving mesh is required for the analysis method based on computational fluid dynamics. To this end, a moving mesh strategy for large deformation of the boundary was presented. The strategy which is based on the mapping interpolation method reflects the displacement of boundary mesh to flow field mesh using a certain kind of weight and then updates the position of mesh nodes. Inverse distance’s nth-power was chosen as the weighting factor and the influence of different weight index n on the mesh deformation was studied, then the analysis of some two-dimensional and threedimensional moving mesh cases was carried out. The results suggest that this method is capable of handling the large deformation and ensuring the quality of deformed mesh.