The construction mode of manned lunar spacecraft was designed by using the classic staging combination design method of lunar spacecraft. A preliminary estimation of the rocket carrying capacity was made according to the analysis of the different staging methods, and the exploration schemes of human-machine synergy are obtained as well. The staging method can provide a new solution to orbit transfer vehicle and landing craft design. The mass estimation of lunar craft based on the analysis of different staging options was given, and the corresponding rocket carrying capacity of different flight modes was compared. The study can provide reference to the scheme of our country’s first manned lunar mission.