According to the trajectory tracking problem of hypersonic glide vehicle under great deviation conditions, a new adaptive tracking guidance method in the injection phase was put forward based on the adaptively revised weighting matrix. The main control mode and standard trajectory characteristics were analyzed. The simplified longitudinal motion equations were linearized near the standard trajectory. An improved adaptive tracking guidance method was designed by introducing the error term in linear quadratic performance index. The simulation results of CAV-H indicate that this method can achieve a great performance in adaptive tracking guidance in the injection phase, and has a good robustness to the initial and process deviation.