A coupling control strategy was proposed for the BTT (banktoturn) flight phase of hypersonic vehicle, according to the strong coupling among the channels of pitch, yaw, and rolling. Based on the nonlinear generable predictive control method, a hierarchy-structured predictive controller was designed and analyzed for rotation motion dynamics of a generic hypersonic vehicle, which has the characteristics of fast variability, high nonlinearity, and uncertain parameters. After analyzing the main influence factors and their effect laws during the BTT flight phase, a coupling control strategy called “decrease angle of attack—rolling fast—increase the angle of attack again” was proposed. Simulation studies were conducted to investigate the feasibility of the proposed control strategy for the hypersonic vehicle. The simulation results demonstrate that the proposed control strategy lowers the control requirement of yaw channel, lowers the probability of being out of control in the BTT flight phase, and increases the reliability of the control system.