In order to explore the relations between design factors of the launcher and performance of the produced hypervelocity fragment, the AUTODYNTM-employed numerical simulation towards launch process was performed repeatedly under the orthogonal experiment design framework. Design factors include explosive type, diameter ratio of charge, material type, thickness, taper angle and radius of the top close to charge chamber for liner part were considered. Multiple target launcher designs were demonstrated: three of which were capable to provide the red copper fragment with the mass of 1.563 g, the aluminum fragment with the velocity of 11.649 km/s and the aluminum one with the kinetic energy of 856 kJ respectively; two of which can produce compact cylindrical fragments with the mass over 1 g and velocity over 11km/s simultaneously. The associated experimental validation was confirmed as well and a further analysis of the design factors was made which explains how they were related to the mass, velocity and kinetic energy of generated fragment.