In order to meet the complexity and uncertainty of virus diffusion in cyberspace operation, escape status and quarantined status were introduced into the virus diffusion model based on a traditional diffusion model, and its stability was discussed. The escape and quarantined mechanism of cyberspace operation was introduced. Via Routh stability criterion, the local stability of system equilibrium point was demonstrated as well as the basic reproductive number R0. Simulations were given to illustrate the influence of node connectivity, node distribution density, and node contact ratio on information diffusion. The results show that the information diffusion can be effectively controlled by changing the parameter regulations on node connectivity, node distribution density, and node contact ratio.