Based on traditional corrugated core structure,a structure-thermal protection integrated structure was designed for missile in severe aerodynamic and thermodynamic environment. The coupled thermo-mechanical numerical model was established to analyze the structural loading capacity and thermal protection performance of the integrated structure, and results show that the integrated structure has good loading capacity at high temperature and the thermal protection efficiency can be improved by increasing thickness of structural thermal insulating layer and inner wall. Aimed at maximum thermal protection efficiency and minimum structural mass, non-dominated sorting genetic algorithm-Ⅱmethod was adapted to achieve multi-objective optimization. The optimization results show that the thermal protection efficiency factor and structural mass of the integrated structure interact with each other, so it needs comprehensive consideration when designed.