To consider the real excitation characteristics of propeller, the measurement experiment of stern fluctuating pressure and underwater hull vibration response induced by propeller in stern wake field was conducted in circulating water channel. The experiment results show that:the fluctuating pressure has the maximum amplitude at BPF(blade-passing frequency), increases with the increase of the propeller load and decreases with the increase of the distance to propeller; the four-blade-propeller has larger amplitude at high wake region after rudders while the five-blade-propeller at low wake region between rudders; the vibration response amplitude at most of the monitor points increases with the propeller load, but there are cases that have less amplitude at BPF and no increase with propeller load; the lateral vibration induced by five-blade-propeller increases while the axis vibration decreases compared with four-blade-propeller; the vibration response amplitude at specific peak frequency presents the 1st order bending mode, and its frequency range relatively agrees with the numerical result of finite element method. The computational fluid dynamics, finite element and modal superposition method were combined to establish a numerical method to evaluate propeller induced vibration response of underwater hull. The comparison between numerical and experiment results illustrates that the numerical results provide a good agreement with the experiment results and are closer to reality than the harmonic response analysis method which uses unit harmonic excitation.