In order to improve the effect of the shape optimization design, the influence of the flight profile with large-airspace and wide speed range for new type of vehicles on aerodynamic shape was studied and a new shape optimization design method based on the aerodynamic and trajectory integrated model was proposed. By this method, the aerodynamic and trajectory integrated model was constructed by using the CST(class/shape function transformation) parametric method, engineering estimation and the Radau pseudospectral method. To implement the efficient global optimization within multi-constraints, an aerodynamic shape optimal design method based on Kriging surrogate model was proposed after clearing the optimization target and constraint condition. The shape optimization design for a type of lifting body vehicles was carried out. It is shown that the aerodynamic and trajectory feature of large-airspace and wide speed range can be better described, and the accuracy and performance of the shape optimization design are improved, which can provide technical support for the conceptual aircraft design.