The initiation Speculiarity of the solid explosive charges under combined compression-shear loading is investigated in this paper. Two kinds of experiment about compression-shear loading have been carried out，one is the experiment in which compression-shear loading is realised by using the normal impacting quartz，and the possibility of chemical reaction taking place in the charges is analysed according to the movement of different partictcs inside the charge specimens measured dy means of electric-magneti particle velocity method；the other is the experiment in which the loading is realised by means of parallel inslant impact method on the compression-shear gun，and the possibility of charge explosion is observed. The experiments show that when the compression stress is under condition of sub-detonotion,the shear stress combining in the loading will play, a role in sensitization of the charge initiation a more sensitive initiation response of explosive is caused by the compression-shear loading under moderate proportion. Experimental analysis of rules and mechanism of the initiation response of explosive is presented in the paper