Using multilevel control method. we studied the coupling active control of the large flexible structures in this article. Taking the dynamic variables of structure as the system states directly, the feedback gains of this vibration system have been developed. According to the theory presented in this article, one space station model has been taken as an illustrated example. The computer simulation has been carried out and the satisfactory results have been gotten. Theoretical and numerical results show that the method presented in this article is of many special advantages to the vibration system of large flexible structures.