Based on TMS320L F2407, a micro-computer control system used for an active heave compensation crane is designed. The working principle and function request of the control system is analyzed. The designing of the kernel of the DSP control system and the peripheral circuit were described in detail. The foreword channel, RS-224 serial man-machine interface, backward channel and the whole DSP control system software were designed, and the simulations were done with the MATLAB. The control system was implemented in a reduce-scaled prototype of the active heave compensation crane, and the test results show that the prototype works with a stable state of the active compensation character.