New requirements for design of Supersonic Cruise Missile(SCM) have been brought forward with the technology development of defense systems. The technology of SCM general scheme design centering on a core of effectiveness was discussed preliminarily in this paper, considering the deficiency of traditional performance based design method for the new design requirements of SCM. Development of design technology for missile weapons abroad was firstly analyzed, and it is pointed out that the design technology is oriented toward a direction of effectiveness-centered design; the concept of effectiveness based design is brought forward, which is a certain kind of optimal design of pursuing a satisfying design; technology frame with penetration effectiveness based design was constructed under such new design concept. Main aspects were concentrated on the penetration effectiveness based SCM design frame, foundation of the penetration effectiveness, foundation of the technology, basic modes and several key technologies, etc.