Comprehensive evaluation for hypersonic vehicle trajectory optimization algorithm has good reference value on selecting optimal trajectory optimization algorithm. According to the features of hypersonic vehicle, trajectory was decomposed into ascent, cruise and descent stages; the performance evaluation indices of each stage and the typical methods of weighting for performance evaluation index were given respectively. Combining with the analysis theory of grey correlation degree, a comprehensive evaluation method of trajectory optimization algorithm was proposed. The calculation results show that the method can quantitatively evaluate trajectories produced by trajectory optimization methods and sort the alternative optimization methods by merits.