A three-dimensional IGC (integrated guidance and control) approach based on fuzzy disturbance observer was proposed to take advantage of the coupling between the centroid motion, and the attitude motion, and of the uncertainties of a hypersonic vehicle in dive phase as well. An IGC model that can be applied to bank-to-turn control strategy was proposed according to the dynamic equations of the vehicle and the line-of-sight relative motion between the vehicle and the target. The uncertainties in the model were compensated by utilizing the fuzzy disturbance observer, and then an IGC approach was developed by using the block dynamic surface backstepping control method. The states of the closedloop system were proved to be uniformly ultimately bounded by adopting proper Lyapunov functions. Simulations show that the IGC method is robust to the uncertainties and satisfies the required performance. 