To solve the high dynamic pressure testing problem while ballistic missile is in flight testing with high-altitude launch site, a test trajectory design method for simulating high dynamic pressure condition was proposed. Firstly, aimed at the actual characteristics of launch site, the dynamic model of wreckage reentry and the impact area boundary model were established. Then, the high dynamic pressure simulated condition was transferred to a process constraint, and a powered phase united optimization strategy was proposed. Based on the adaptive simulated annealing algorithm, three test trajectories meeting different high dynamic pressure simulated conditions and all constraints were designed separately, meanwhile the impact area adjusted program was generated correspondingly, and its feasibility was demonstrated. Results illustrates that the maximal dynamic pressure occurs in the first stage, the maximal negative angle of attack in the first stage contributes to improve the maximal dynamic pressure greatly; the warhead impact point constraint of test trajectory can be guaranteed by adjusting launching azimuth and the pitch program angle of the second and the third stage at the same time.