The unmanned swarm combat is becoming a new type of style that changes the form of warfare. As the relatively independent testing of unmanned equipment and the lack of integrated closed-loop design and integrated verification methods, a system-of-system (SoS) design and simulation evaluation method is proposed in this paper. The method includes five stages: the combat concept modeling and demand analysis, the SoS design concept and SoS design, the infield simulation experiment and scheme exploration, the system prototype development and evaluation optimization, the completion of integrated testing and comprehensive decision-making. In addition, we innately develop the theoretical methods, tool links, and integrated environment of the SoS design, simulation tests, evaluation and optimization, where provide theoretical and technical support for the systematization, intelligence, and actual combat level of unmanned equipment.