Currently, countries around the world are generally unable to defend effectively against high-speed vehicles, and related basic research is still in its infancy. Accelerating the development of high-speed target defense technology is crucial for maintaining aerospace security. Given the problems present in the near-space defense confrontation under this background, such as a narrow defensive posture, significant speed disadvantages, and limited single-missile defense capability, this paper reviews the current development status of the defense guidance law for high-speed near-space vehicles. It analyzes the deficiencies of the existing guidance law research from perspectives such as complex offensive and defensive confrontation scenarios, missile cooperative guidance mechanisms, and real environment effectiveness constraints. It also foresees the key development directions of future defense guidance laws for high-speed vehicles, aiming to offer references for the construction of future defense systems for high-speed vehicles and the frontier basic research in the field of precision guidance.