Traditional missile design procedure cannot achieve synergic design of subsystems well. Multidisciplinary design optimization technique is very suitable for multidiscipline synergic design in modern computer network environment. We introduce coevolutionary algorithms to multidisciplinary design optimization based on their substantial similarity, to sufficiently employ the merit of evolutionary algorithmsin MDO. A multidisciplinary design optimization method based on cooperative coevolutionary algorithms is presented. The algorithm is applied to missile aerodynamic/engine/control multidisciplinary design optimization, and result shows it's ability in design optimization of coupled systems.