The percutaneous coronary intervention virtual simulation system about coronary heart disease is one of the important tools for medical intervention training. To satisfy the clinical training needs, the key techniques about geometry modeling, heartbeat simulation, liquid simulation and flexible instrument movement processing in systerm development were discussed. A blood vessel model based on NURBS surface and a heartbeat model based on a combined mass-spring were proposed. Contrast media injection and flexible instrument movement were realized by the particle systerm and the multi-branch tree method. A simulation platform and technology support was supplied for percutaneous coronary intervention training. 