Considering the highdynamics, incomplete information and uncertainty of massive operations, on the basis of the analysis and induction of a methods was proposed to solve the problem of dynamic weapon target assignment, a comprehensive mathematical of dynamic game based on both sides was made in structure, a phased solution was provided based on Nash equilibrium algorithm and Pareto optimization. The results validate that combining the mathematical model with the game theory method can effectively deal with the problem of dynamic weapon target assignment efficiently.