With regard to accurately predicting thermodynamic environment for air-to-air missile, fluid-thermal-solid coupling analysis should be adopted, and coupling effects on flow field and structure-temperature field should be investigated. A fluid-thermal-solid multi-field coupling simulation model for air-to-air missile was established via using partition algorithm, and the coupling relationships among missile structural deformation, temperature and pressure were analyzed and the coupling effects on temperature and pressure simulation results were examined as well. Results show that, missile bending deformation is caused by aerodynamic and aerothermal, and the structure deformation could lead to the variation of missile temperature field and pressure field. The main reason for the variation is induced by the structure deformation from aerodynamic effect. The predicting accuracy of missile thermodynamic environment can be affected by the coupling effects. If the missile slenderness ratio or the angle of attack is small, or the flight speed is low, the coupling effects have a little influence on thermodynamic environment for supersonic missile. If the missile slenderness ratio and the angle of attack are large, and the flight speed is high, high predicting accuracy can be obtained by considering coupling effects.