Fiber hybridization is one of the effective means to improve the toughness and ductility of fiber-reinforced polymer matrix composites, hence avoiding their catastrophic brittle failure. The interlaminar fracture toughness is an important factor affecting the mechanical behavior of fiber hybrid composites. In this paper, two kinds of epoxy resins with different toughness, 7901 and 9A16, were used as the matrix. Interlayer carbon/glass hybrid composites with different numbers of carbon fiber layers were designed and manufactured. The effects of mode Ⅱ interlaminar fracture toughness (GⅡC) on the failure mode and mechanical properties of carbon/glass hybrid composites were investigated through both theoretical and experimental investigation. The results showed that, the higher mode Ⅱ interlaminar fracture toughness was, the more the carbon layer tended to fail in fragmentation, which was beneficial for achieving pseudo-ductility. In addition, the GⅡC on the modulus and strength of hybrid composites was marginal